Pre-implantation Genetic Diagnosis (PGD) is performed in conjunction with in vitro fertilization (IVF). PGD detects the genetic abnormalities either at gene level or at chromosome level before transferring the embryo into the uterus to avoid the transfer of genetically affected embryos. PGD is offered for three conditions:
PGD-AS is the most common type of PGD analysis. The embryos are tested using a panel of chromosomes that are commonly involved in miscarriages or trisomy pregnancies. Embryos screened this way and reported as normal have a higher rate of implantation, lower spontaneous loss and a reduced risk of trisomy offspring (e.g., Down’s syndrome).
One partner may carry a gene for a dominant disorder as in
X-Linked Inherited Diseases An X-linked disorder requires just one copy of the mutated gene, inherited from an affected parent (males are affected and females are typically unaffected carriers)
This procedure involves prior testing to detect the gene mutation so that a gene probe can be produced.
There are several possible reasons for failure to achieve a successful identification of the gene or to achieve pregnancy. These include:
Chromosomal translocations involve a rearrangement of the chromosome material so that some of the genetic material from one chromosome is located on another one. This is known as a “balanced” translocation where all of the normal genetic material is present.
© All Copyrights 2023 by Multitalentit.com