Ovulation Induction

Ovulation induction is the method for treating An-ovulatory Infertility.

Hypogonadotrophic Hypogonadism (Hypothalamic-Pituitary Cause)

Treatment involves administration of both Follicle stimulating Hormone and Lutinising Hormone, while Human Chorionic Gonadotrophin is injected for follicle rupture.
Pulsatile Gonadotrophin Releasing Hormone has the same effectiveness as Gonadotrophins with the advantage of low multiple pregnancy rates.

First treatment of choice is Clomiphene Citrate CC. In properly selected PCOS patients, the cumulative pregnancy rate using CC approaches that of normal women.
Low-dose Follicle stimulating Hormone protocols are the second line of treatment and are effective in inducing monofollicular development.
Laparoscopic Ovarian Drilling can be an alternative but not as a first choice treatment in Clomiphene Citrate-Resistant patients.
Pulsatile GnRH and GnRH agonists, are hardly used today in PCOS.
In obese women with PCOS, weight loss and exercise should be recommended as the first line of therapy.
Aromatase Inhibitors are not necessarily helpful PCOS.
Insulin Sensitizers can help if added to CC in obese PCOS patients.

St George Clinic